ABSTRACT
The proceedings contain 31 papers. The topics discussed include: migraine with aura in the population of Buenos Aires, Argentina: association analysis of 6 SNPs;mnemonic method in Portuguese for headaches in ER;patterns of libido, sexual activity and sexual function in female migraineurs;algorithm in the preventive treatment of cluster headache in Mexican patients;monoclonal antibodies in patients with migraine. experience in a headache service;analyzing cortical expression patterns of migraine-associated genes: A new perspective on migraine genetics;impact of COVID-19 pandemic lockdown on migraine patients in Latin America;long-term effectiveness of combined unilateral sphenopalatine and occipital nerve stimulation in patients with refractory chronic cluster headache;a neuropsychological profile-based classification outperforms ICHD-3 in terms of disability: exploratory analysis with anatomical correlates;strategic planning for the headache committee of the Colombian Association of Neurology-ACN - proposal;and botulinum toxin a in the preventive treatment of chronic migraine;experience in Argentine headache center.
ABSTRACT
Curvularia species are dematiaceous filamentous fungi that can cause a variety of infections in both immunocompetent and immunocompromised hosts. We present 2 cases of severely immunosuppressed patients with acute invasive fungal sinusitis due to Curvularia species. Both patients had a history of hematologic malignancy with refractory disease and prolonged neutropenia. They presented with facial and sinus pain, which prompted maxillofacial computed tomography that showed acute sinusitis. Subsequently, they underwent nasal endoscopy with a biopsy that revealed a definitive diagnosis of invasive fungal sinusitis. Dematiaceous fungi are responsible for most fungal sinusitis cases, with Curvularia being one of the most common species isolated. Generally, invasive fungal rhinosinusitis may follow a relatively innocuous and nonspecific course. In addition, fungal infections may complicate chronic allergic sinusitis. Computed tomography scan is the first imaging modality of choice, and magnetic resonance imaging has a role in prognostication in acute invasive fungal rhinosinusitis. Endoscopic sinus surgery with biopsy yields a definitive diagnosis and is therapeutic. Management typically includes a combination of surgery and antifungal agents. Severe neutropenia is a significant risk factor for infection and is associated with poor outcomes. Aggressive surgical debridement, combined with antifungal therapy, should be emphasized in leukemic patients despite their prolonged neutropenia and bleeding tendency.